In which century was the emphasis on mining and its related health issues highlighted?

The emphasis on mining and its related health issues became particularly notable in the 15th century. During this time, the advancement of mining techniques and the increased demand for metals led to a focus on the health effects experienced by miners. Reports of ailments caused by dust exposure and the utilization of hazardous materials like mercury began to surface, bringing attention to the occupational hazards prevalent in the mining industry. This period marked a significant recognition of the impact of working conditions on miners' health, which paved the way for later developments in occupational health standards. The other centuries listed did not see as concentrated a focus on the mining-related health issues compared to the emerging industrial and scientific advancements of the 15th century.